Decision Modeler Report

COVID19 Lab Findings Poor Prognosis Brigham Womens

Published: 4/14/2020

By: John Svirbely MD

Table of Contents

COVID19 Lab Findings Poor Prognosis Brigham Womens

Overview

COVID19 Lab Findings Poor Prognosis

Decision Requirement Diagram

Elements

COVID19 Lab Findings Poor Prognosis Brigham Womens

Overview

A number of laboratory findings are associated with a poor prognosis for a patient with COVID19. These reflect high risk complications (ARDS, multi-organ failure, DIC, myocarditis, cytokine release, etc).

COVID19 Lab Findings Poor Prognosis

Decision Requirement Diagram

Elements

Is the patient at increased risk for poor prognosis? (Decision)

Decision Logic (Decision Table)

Is the patient at increased risk for poor prognosis?

F

Number of laboratory findings associated with a poor prognosis

Is the patient at increased risk for poor prognosis?

Description

"Yes", "Probably", "No"

1

0

"No"

2

1

"Probably"

3

>=2

"Yes"


References (Knowledge Source)

Description

Yan L, Zhang H-T, et al. Prediction of criticality in patients with severe Covid-19 infection using three clinical features: a machine learning-based prognostic model with clinical data in Wuhan. 2020. doi: 10.1101/2020.02.27.20028027. medRxiv.org

 Zhou F, Yu T, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020. doi: 10.1016/S0140-6736(20)30566-3.

Number of laboratory findings associated with a poor prognosis (Decision)

Decision Logic (Decision Table)

Number of laboratory findings associated with a poor prognosis

C+

Elevated plasma Ddimer

Elevated serum creatinine

Elevated serum troponin

Moderate to marked elevation of serum CRP

Moderate to marked elevation of serum LDH

Severe absolute lymphopenia

Severe hypoxemia

Number of laboratory findings associated with a poor prognosis

Description

1

false

-

-

-

-

-

-

0

2

true

-

-

-

-

-

-

1

3

-

false

-

-

-

-

-

0

4

-

true

-

-

-

-

-

1

5

-

-

false

-

-

-

-

0

6

-

-

true

-

-

-

-

1

7

-

-

-

false

-

-

-

0

8

-

-

-

true

-

-

-

1

9

-

-

-

-

false

-

-

0

10

-

-

-

-

true

-

-

1

11

-

-

-

-

-

false

-

0

12

-

-

-

-

-

true

-

1

13

-

-

-

-

-

-

false

0

14

-

-

-

-

-

-

true

1


Moderate to marked elevation of serum LDH (Input Data)

Elevated serum creatinine (Input Data)

Elevated serum troponin (Input Data)

Elevated plasma Ddimer (Input Data)

Moderate to marked elevation of serum CRP (Input Data)

Severe absolute lymphopenia (Input Data)

Severe hypoxemia (Input Data)